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Notably, the same signature is recapitulated in multiple ALS mouse models, where GPX4 loss in the spinal cord occurs early and universally during disease development [235]

In rats, VitB12 can inhibit protein kinase C (PKC) and, in turn, suppress voltage-dependent Ca 2+ channel activity, decreasing Ca 2+ influx into synaptosomes [101]

Metformin and intermittent fasting mitigate high fat-fructose diet-induced liver and skeletal muscle injury through upregulation of mitophagy genes in rats

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