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As a result, Gclc deficiency causes lethal autoimmune responses and enhances antitumor immunity [217]

7 Clinical outcomes of pharmacotherapy To date, numerous clinical studies including double- or single-blinded randomized clinical trials and split-face studies have been conducted to assess the therapeutic effect of various topical conventional and novel formulations in melasma management as summarized in Table 3

Sleep deprivation can interfere with the production of melatonin and disrupt the body's normal sleep-wake cycle which can in turn lead to problems such as fatigue, irritability, and difficulty concentrating