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Description
Nat Commun 16 , 11181 (2025)
SAM is subsequently transformed into SAH and then to homocysteine, which can either be remethylated back to methionine or shunted into the transsulfuration pathway to generate cysteine and GSH
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Drugs cleared by hepatic glucuronidation caution (SAMe may speed clearance): paracetamol (acetaminophen), diazepam and morphine
