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Similar content being viewed by others Introduction The ability of cells to sense and respond to nutrient availability is critical for cell survival

Discussion In the present study, we confirm that Gsdmd cKO in SCs largely reduced the threshold elevation and OHC loss caused by noise exposure (2 h, 100 dB SPL), while no protection effect was observed in Gsdmd -HC-cKO mice

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Notably, its role in ferroptosis is biphasic: while high, exogenously delivered concentrations of NO can induce this iron-dependent cell death, lower, endogenously regulated levels can be protective by terminating lipid peroxidation