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Dongre and Swami performed an open label study of pain response in patients with peripheral neuropathy who received oral sustained release pregabalin of doses of either 75 mg or 150 mg, which were given along with oral methylcobalamin 1500 g for a duration of two weeks ( n = 384)

While peptides are generally well-tolerated, monitoring allows early detection of elevated IGF-1, insulin changes, liver enzyme shifts, or other markers that warrant protocol adjustment

Folate and vitamin B12 are important cofactors of this mechanism, acting in the one-carbon metabolism
