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To assess the risk associated with elevated Lp(a) and the effects of interventions that reduce Lp(a) and other risk factors, use the calculator available at: These recommendations are particularly important because recent results from the OCEAN (a)-Dose study indicate significant long-term individual variability in Lp(a) levels in patients with ASCVD and elevated baseline Lp(a) concentrations, suggesting that it may be necessary to measure this parameter more than once in a lifetime [109]

Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency