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Safety, tolerability, pharmacokinetics, and pharmacodynamics of the first-in-class GLP-1 and amylin receptor agonist, amycretin: a first-in-human, phase 1, double-blind, randomised, placebo-controlled trial

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In the lowamyloid group (comprising individuals who started treatment when lower amounts of betaamyloid had accumulated), the time to progression from MCI to mild dementia was 13.2 years, suggesting a time savings of 6 years compared with the untreated group