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Description
Citrulline improves renal NO levels and attenuates hypertension in SS and SHR rats 87,129,130
The RNA interference (RNAi) is a method of silencing specific genes using double-stranded RNA that can be used to reduce the expression of mutant proteins by fully or partially complementary pairing with the target mRNA, which can lead to the degradation or translational repression of mRNA (36)

Additional studies will be necessary to determine if negative allosteric modulators of CB1 have improved safety and tolerability profiles when compared with inverse agonists

Overall, structural alterations found in SURF1 and other LS mutant organoids confirmed the dysregulation of NPCs function and morphogenesis as a relevant mechanism in the pathophysiology of LS
