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In Ldlr / Leiden mice, only the combined intervention with nicotinamide riboside, rather than either monotherapy, significantly attenuated obesity and hepatic steatosis, accompanied by coordinated upregulation of genes involved in fatty acid oxidation and insulin signaling (61)

Previous studies have highlighted the critical role of the gut microbiota in influencing the immune response and tumor progression, suggesting that altering the microbial composition could enhance the efficacy of existing treatments and mitigate resistance mechanisms

Evidence Review for Dietary Guidance: Technical Report