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MiR-10b was proven to inhibit the pro-apoptotic BIM, a Bcl-2 family member, and results in the chemoresistance of 5-FU in CRC cells (Nishida et al., 2012)

The recommended phase 2 dose (RP2D) for cabozantinib was 40 mg daily and the trial was expanded to a phase II multi-cohort, multi-center trial of 117 patients (Saeed et al., 2023)

Moreno-Montanes, J., Bleau, A

The researchers performed quantitative susceptibility mapping (QSM) iron deposition in the SN of 44 PD patients and 31 age- and sex-matched healthy controls and PD patients were found to exhibit significantly higher magnetic sensitivity values, especially in patients at advanced stage severity, confirming that iron accumulation in SN is consistent with PD progression (Moreau et al., 2018), and it might be a chance to cure PD in the future
