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Simultaneously, copper functions as a co-factor of various proteins and enzymes, including cytochrome C, superoxide dismutase, tyrosinase, ascorbate oxidase, lysyl oxidase, and amine oxidase, exhibiting diverse fundamental cellular functions in normal physiology, including energy generation, iron acquisition, oxygen transportation, cellular metabolism, peptide hormone maturation, blood clotting, neurotransmitter biosynthesis, and intracellular signal transduction (Huffman and OHalloran, 2001

Pract., Article ID 361078 (2013)

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doi: 10.1016/j.jbc.2021.101456 50 LiSYSongZYanYPLiBSongMJLiuYFet al