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Infertility Inform patients that chronic use of opioids may cause reduced fertility

Initially, it can increase heart rate and blood pressure, primarily due to its stimulating effects on the heart and its ability to increase catecholamine release

Therefore, it is better to use specific TKIs based on the overexpressed tyrosine kinase in each cancer type [165]

In rat cardiomyocytes, zinc overload elevates ROS and disrupts mitochondrial membrane potential, triggering PINK1/Parkin-mediated mitophagy and impairing mitochondrial dynamics and biogenesis, with mitofusin 2 (Mfn2) playing a protective role in mitigating zinc-induced mitochondrial damage 151