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Animal reproduction studies with semaglutide have shown embryofetal toxicity, including structural abnormalities, at exposures below those expected at therapeutic doses in humans

However, when dysbiosis occurs, there may not be enough Lactobacilli to disrupt biofilms

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Of obvious relevance to our findings, GSTP1 has recently been shown to be an IL-6 target gene (Wang et al, 2010), while inhibition of GSTP1 activity by an IL-6 or IL-6 receptor mAb correlates with increased platinum (and paclitaxel) sensitivity in renal cancer cells (Mizutani et al, 1995)