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Additional studies describe exploratory evaluation of peptide-associated signaling environments and interaction dynamics in preclinical models, including observations related to peptide integrity and comparative behavior when examined individually or in combination

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These findings should be overseen with glutamate as the major excitatory neurotransmitter in the central nervous system (i.e., cognitive functions such as learning and memory in the brain [200], the precursor of major inhibitory neurotransmitter GABA) but excitotoxic neuronal death as a direct result of high concentrations [201], and tight physiologic range that should be maintained [59]