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Patients considering these treatments should understand the evidence base, safety considerations, and appropriate clinical indications before proceeding

Since tirzepatide may slow gastric emptying as part of its mechanism of action, patients with pre-existing severe gastroparesis could experience worsening of symptoms, including nausea, vomiting, and potential complications related to delayed gastric emptying

Known as peripheral sensorimotor polyneuropathy, this condition usually first occurs equally in both feet and can spread from tingling, pain and discomfort to paralysis

Limitations of Evidence Limitations of Evidence Animal-dominant data: Most findings are from rodent and cell models