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Homocysteine level is a more direct measure of the function of vitamin B12 and folic acid (compared to red blood cell or serum testing)

The cells treated with L-GSH may also have synthesized additional endogenous GSH since the cytokines IL-6 and TGF- are known to decrease GSH synthesis and these cytokines were found to be decreased in the cultures treated with L-GSH [12,13,15,16], (Figure 3 and Figure 4)

Detection of cellular glutathione and oxidized glutathione using magnetic-plasmonic nanocomposite based turn-off surface enhanced Raman scattering

Some of these mechanisms are discussed below and summarized in Figure 1