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About 28 percent of sections of normal-appearing skin from patients with acne show histologic features of microcomedones, the subclinical precursors to both inflammatory and noninflammatory acne lesions, and biopsy of papules demonstrates the presence of microcomedones in 52 percent of patients with acne

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vaginalis , the bacterium has the capacity to produce biofilm, adhere to the epithelium and produce cytotoxic components [61, 62]