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The degradation process of tryptophan in KP produces a variety of neuroactive metabolites with amino acid-like structures, such as an N-methyl-D-aspartate (NMDA) receptor agonist quinolinic acid (QA), and a neuroprotective NMDA receptor agonist kynurenic acid (KYNA)

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Then, glutamic acid is deaminated to ketoglutarate by GLUD1/glutamate dehydrogenase (GDH) enzyme or various aminotransferases to produce other non-essential amino acids

Indeed, hyperinsulinemia-mediated increases in TKT expression are directly correlated to the development of MAFLD
