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253 ROS can also indirectly activate HIF1 through pathways such as the AMPK, PI3K/AKT, and MAPK pathways, which phosphorylate HIF1 at specific residues (e.g., Ser419, Ser641, and Ser643) 254,255 (Table 1, Fig

10.1029/2004GL021592 84 LiaoC

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