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Pain-related outcomes such as burning sensation, and spontaneous pain were all significantly reduced in both groups at the 12-week endpoint of the study

Consult a doctor if you have a history or suspicion of prostate or breast cancer, high blood calcium levels, fluid retention leading to ankle swelling, or sleep apnea with interrupted breathing during sleep

PMID 20445536.

Furthermore, a vitamin B12 deficiency is also known to cause dark circles
