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Along with the rapid development of materials science and nanotechnology, various strategies for BBB regulation and crossing have been developed and engineered delivery systems with unique physio-chemical properties and multifunctional motifs were prepared for enhanced drug delivery via different BBB crossing pathways

This selectivity represents a paradigm shift in antioxidant therapy: Hydroxyl radical specificity : Molecular hydrogen primarily neutralizes hydroxyl radicals (OH), considered the most cytotoxic reactive oxygen species with no known endogenous detoxification system, while leaving beneficial oxidative molecules intact

S-glutathionylation has been shown to regulate the activity of numerous transcription factors and signaling proteins, including those in the NF-B, AP-1, and MAP kinase pathways (e.g., JNK, p38)

The synthesis of Ru-hydroxide was achieved by dispersing and stirring 50 mg of the as-prepared hydroxide in 50 mL aqueous RuCl 3 xH 2 O (10 mg) solution under ambient conditions for 24 h