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In conclusion, we demonstrate increased levels of cell death in ADA2-deficient cells that are not due to RCD pathways and establish an impaired pentose phosphate pathway as a potential cause of this phenotype

Ten volumes of ice-cold diethyl ether were added to the combined filtrates and the mixture allowed to set at 4C overnight

By contrast, a recent study revealed that B cells from MS patients exhibited an increased level of activated NF-B p65 following CD40 stimulation compared with healthy controls (74)