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In vivo , adding hydroxycitrate (250 mg/kg) and LA (10 mg/kg) to cisplatin or methotrexate was more effective against tumour development than individual chemotherapeutic drugs or the combination of lipoic acid and hydroxycitrate administered [106]

breast, colon and prostate), pulmonary and metabolic diseases (115)

GP1 is found in the cytoplasm of nearly all mammalian tissues, whose preferred substrate is hydrogen peroxide

A promising approach to enhancing therapeutic outcomes involves targeting mechanisms of CICD, including inducing ferroptosis by SLC7A11 inhibition, modulating mitochondrial ROS generation, or combining inhibition of autophagy with chemotherapy