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Intervention Strategies: Anti-VEGF neutralizing antibodies (e.g., bevacizumab/B20) or anti-angiogenic tyrosine kinase inhibitors (e.g., axitinib), by blocking VEGF signaling, not only reduce pathological angiogenesis, edema, and hemorrhage but also decrease peripheral nerve density mediated by the interaction of VEGF with neuropilin (NRP), thereby alleviating pain

While NMN has been available in the past as a dietary supplement, it's not currently classified as a dietary supplement in the United States, due to its investigation as a potential pharmaceutical drug

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Other disorders related to vascular obstruction, particularly stroke and retinopathy leading to loss of visual acuity and even blindness, can take a devastating toll