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The use of fluorescence resonance energy transfer-based biosensors of various GPCRs indicated the formation of distinct ligand-specific receptor conformations (Kim et al., 2022), and recent technical advances have revealed a far wider and more dynamic range of receptor and -Arr conformations that are ligand and receptor specific (Lee et al., 2016

We have investigated whether these differences in methodology could have contributed to the substantial increase in EGRAC values reported in the 2003 NDNS compared with the 1990 NDNS of UK adults