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Additionally, a comparison of DN4 scores between patients with vitamin D deficiency and those without deficiency was conducted, and a significant statistical difference was also observed between these two groups ( p = 0.273) (Table 2)

These findings collectively identify the FOXO4-p53 axis as a potential pharmacological target in brain aging and highlight senolytic therapy as a promising strategy for altering diseases to postpone or reverse age-related cognitive decline

Carboxylated multiwalled carbon nanotubes block the assembly of the NLRP3 inflammasome through their surface negative charge, reducing the release of IL-1 and IL-18 and inhibiting ischemiareperfusion neuroinflammation