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Depending on the involved loads and direction of force, it can range from a subclinical strain of some annular fibers (whiplash injury) that would be referred to the disc injury type A1 over a traumatic disc herniation (injury type B) to a complete dislocation with separation of the segment, disruption of the annular fibers, longitudinal ligaments, joint capsule and posterior structures (disco-ligamentous complex, DLC) that would be injury type C

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The pathogenesis of excitotoxicity in PD is complex, and its treatment strategies are multifaceted

In the context of early brain injury following subarachnoid hemorrhage (SAH), topiramate significantly reduced the elevated levels of TNF-, IL-1, and IL-6 induced by SAH, suggesting that topiramate may exert neuroprotection via its anti-inflammatory effects (Tian et al., 2015)