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This earlier loss of free GTP colocalized with mitochondria in 3xTg-AD neurons could be a key component in autophagic impairments in AD
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Under selenium deficiency, the protein expressions and/or activities of seleno-GPxs are decreased in a hierarchical order depending on their importance for cellular viability and functions (Table 1) [8, 25]

the mitigation column below is deliberately conservative, and the recurring theme is that technique and consistency solve more problems than dose changes
