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10.1016/j.avsg.2015.10.036 200

found that either glutamine depletion or inhibition of GLS activity decreased the rate of ATP and oxygen consumption and ultimately induced apoptosis in AML cells [11]

Although carnitine appears as the most frequently altered metabolite, the metabolic pathway of carnitine synthesis appeared significantly altered, only in two investigations (Xu et al., 2020

Unlike GLS2, GLS1 is often overexpressed in many types of cancer, including breast cancer, acute myeloid leukemia, and non-small cell lung cancer, making it a promising therapeutic target for cancer treatment (Van Den Heuvel et al., 2012
