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The dihydropyridine L-type calcium channel blocker Isradipine has been reported to reduce hypoxia-induced activation of Ca 2+ -dependent xanthine oxidases, monoamine oxidases, cytosolic phospholipase A 2 , and cyclo-oxygenases (COX-2) along with a decrease in free radical generation and cytochrome- c release (Barhwal et al., 1991) was also inhibited by Isradipine