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Sex of the animal models To the best of our knowledge, the occurrence of osteosarcoma is not related to the sex of the patient
Kang MJ, Eum JY, Jeong MS, Choi SE, Park SH, Cho HI, et al

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Likewise, the suppressor oncogene p53 is capable of suppressing the activity of the IGF-1R promoter as well as lowering the endogenous levels of IGF-1R mRNA (Werner et al, 2000)
