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In vitro experiments showed FOXO4-DRI to be more potent against senescent cells in which SASP was transiently boosted by recombinant IL1/ or LPS, whereas an IL1 receptor antagonist or the general anti-inflammatory drug Cortisol reduced its potency (Fig
doi: 10.1016/S0006-291X(02)00268-1

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The general occurrence of this dehydroalanine-derived post-translational modification thus makes a strong candidate to search by proteomic-based approaches [210] its presence in inactivated enzymes and in other proteins
