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In colitis, multiple proinflammatory cytokines within the intestinal tissue abnormally activate STAT3, resulting in intestinal barrier dysfunction, hyperactivation of innate immunity, and enhanced Th17-mediated immune responses, all of which contribute to chronic intestinal inflammation (Chen X

At concentrations present in human milk, glutamate could be involved in promoting T H 1 immunity and subsequently in reducing the susceptibility to allergic sensitization, although this remains speculative due the lack of evidence in neonatal cells or animals

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