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doi: 10.3109/13813459509007560 102

At a dose of clomipramine hydrochloride 200 mg, subjects who had a single blood sample taken approximately 9 to 22 hours, (median 16 hours), after the dose had plasma concentrations of up to 605 ng/mL for CMI, 781 ng/mL for DMI, and 1386 ng/mL for both

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Abbreviations PCOS: Polycystic ovary syndrome SHBG: Sex hormone binding globulin FSH: Follicle-stimulating hormone COX-2: Cyclooxygenase 2 CRP: C-reactive protein TNF: Tumor necrosis factor alpha NF-B: Nuclear factor kappa B LH: Luteinizing hormone AR: Androgen receptor DHT: Dihydrotestosterone AMPK: AMP-activated protein kinase GLUT-4: Glucose transporter type 4 IRS: Insulin receptor substrate EGCG: Epigallocatechin gallate SOD: Superoxide dismutase Nrf2: Nuclear factor erythroid 2related factor 2 GPx: Glutathione peroxidase Arg: Arginine Cur: Curcumin CAT: Catalase MDA: Malondialdehyde NAcHis: N-acetyl histidine Bcl-2: B-cell lymphoma 2 DHEA: Dehydroepiandrosterone HFD: High-fat diet PCOS: Polycystic ovary syndrome PPAR: Peroxisome proliferator-activated receptor MAPK: Mitogen-activated protein kinase PCNA: Proliferating cell nuclear antigen cAMP: Cyclic adenosine monophosphate CYP: Cytochrome p450 enzyme FSH: Follicle stimulating hormone LDL: Low-density lipoprotein PCOS: Polycystic ovary syndrome TG: Triglycerides References Guastella E, Longo RA, Carmina E