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If this is the case, a deep understanding of how pH affects biochemical reactions in a systemic fashion may provide a powerful tool to control the progression of renal and extrarenal chronic diseases with deranged metabolism

Two promising strategies are: Senolytics: drugs that kill senescent cells

Krivonos DV, Konanov DN, Ilina EN

Based on these data, ACTH effects on the cardiovascular system are mainly mediated by glucocorticoid systemic effects
