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Melanin turnover rates vary by individual: skin cell turnover (keratinocyte shedding) occurs every 2840 days, and melanosomes are degraded by autophagy within melanocytes over similar timeframes

[PMC free article: PMC4210029] [PubMed: 25246565] 83

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The importance of gut bacteria to human physiology is significant but in the context of digestion these microorganisms produce some vitamins and important nutrients and they digest molecules (particularly complex carbohydrates commonly referred to as non-digestible fiber) that cannot be degraded by human enzymes