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The decision of when to start B12 injections is individual and depends on factors like the severity of the deficiency, the underlying cause, and the patients health status

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In these terms, the effect on the heart (cardioprotection) might be an additional part of the cytoprotective activity (for review, see, i.e., [10,11,12,13,14,15,16,17,121,122,123]), and, in particular, it might be commonly taken as proof and consequence of its innate cytoprotective activity (for review, see, i.e., [2,3,4,5,6,7,8])