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Although medaka and Xenopus offer certain advantages, they are constrained by fewer genetic tools or slower development, rendering zebrafish superior in genetic tractability and immunological assay versatility (Wang and Cao, 2021)

The intrinsic pathway of apoptosis is activated by stimuli that lead to the permeabilization of the OMM and the subsequent release of proteins from the mitochondrial IMS, such as cytochrome c (Martinou and Green, 2001

The risk of alcoholic liver disease by inducing proinflammatory cytokine production and apoptosis is also increased [8]

In phylum Porifera, PRX5 is the only PRX subfamily for which we do not recover a monophyletic demosponge clade, but rather the freshwater (FW) demosponge Ephydatia muelleri branches independently from the three marine (Mar) demosponges (Fig