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Description
MEK1/2 inhibitors suppress pathological -synuclein and neurotoxicity in cell models and a humanized mouse model of parkinson's disease
DECLARATIONS Authors contributions Conceived the design of this article and wrote the first draft
& Raphael, W
Specifically, we identified KU-57788 as a DRP1 agonist that induces excessive mitochondrial fission, which in turn activates the NRF2/SLC7A11/GSH axis as a protective response in ATC cells to mitigate its cytotoxic effects
