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Within the pulmonary milieu, ozone interaction with unsaturated fatty acids can yield lipid ozonation products, engendering lipid peroxidation, perturbed membrane permeability, and subsequent activation of inflammatory mediators [84]

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In in vivo studies, Penna-Martinez et al [41] found that high dose vitamin D treatment significantly downregulates both late-activated CD4 + and CD8 + T cells in patients with Addisons disease