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The result is 100% bioavailability at therapeutic concentrations that oral supplementation cannot reliably achieve

Following these steps should minimize negative outcomes while maximizing positive side effects

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Notably, Nrf2 knockout and small interfering RNA-mediated knockdown experiments revealed that Nrf2 deficiency abrogates the neuroprotective and antioxidant effects of TSA, confirming that Nrf2 activation is the key mechanism underlying the efficacy of TSA (141)
