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Heres what researchers have found: A study from the University of Pennsylvania showed that vaping a nicotine-free product, even just once, can reduce blood flow and make blood vessels less flexible , an early warning sign of vascular damage: "While e-cigarette liquid may be relatively harmless, the vaporization process can transform the molecules -- primarily propylene glycol and glycerol -- into toxic substances

Additionally, acute alcohol administration increases extracellular adenosine by impairing its uptake via ENT1 [81, 82]

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doi: 10.1056/NEJMra0801537