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Description
It has been reported that senescent cells have a secretory phenotype associated with senescence and secrete high levels of inflammatory mediators such as IL-6, IL-1, TNF, IL-18, IL-8, CCL2, CCL11, growth factors, and proteases [28, 34, 35]
10.1080/15548627.2016.1187366 67 IbrahimD.JabbourJ

Other options are available to detect the levels of inositol monophosphate and diacylglycerol, second messengers whose levels rise prior to increases in calcium

Ihsan Orem, Email: [email protected]