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Continuous ROS production results in oncogene and tumor suppressor gene changes, as well as chromosomal abnormalities by oxidative genome damage, which includes the oxidation of guanine to form 8-OhdG and 8-oxo,7,8-dihydroguanosine (8-OHG) in RNA and DNA (100)

Liu H The Amipurimycin and Miharamycin Biosynthetic Gene Clusters: Unraveling the Origins of 2-Aminopurinyl Peptidyl Nucleoside Antibiotics

DOI:10.1016/j.abb.2023.109699 13

Pharmacological or gene inhibition of glutathione transporters, including multidrug resistant protein 1, can block cell GSH release, reduce intracellular ROS levels and production of oxidized phosphatidylcholine, thereby inhibiting cell ferroptosis