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On average, only one out of 5000 to 10000 medications would get approved after significant investment by pharmaceutical companies [271]

10.1016/j.celrep.2013.06.018 65 ChiuehC

The degeneration of dopaminergic neurons is the main pathophysiological attribute of PD, which is accompanied by a decrease in dopamine secretion (2), and over time, motor (tremor, muscle rigidity, slowness of movement, and imbalance) and non-motor (postural hypotension, depression, sleep disorders, hallucinations, fatigue, and pain) symptoms appear (3)

TB-500 is known for its systemic anti-inflammatory properties and its role in cell migration and differentiation