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10.3390/biomedicines9070792 42 KolovratM.GojkovicS.KrezicI.MalekinusicD.VrdoljakB.Kasnik KovacK.et al (2020)

Nanoparticulate drug delivery systems have shown important advantages in stability and bioavailability, such as: protection of the drug from premature degradation and interaction with the physiological environment increased intracellular penetration increased solubility of insoluble drugs enhanced drug absorption [3] Smaller particles have larger surface area, which improves bioavailability The research has shown that smaller particles, preferably of 100 nm [4], significantly improve the bioavailability of the drug

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The critical distinction is lyophilized versus reconstituted