![methotrexate glutathione Inhibitory effect of on NADPH-dependent oxidoreductases [6] the principle source of cellular energy Attenuation of methotrexate induced hepatotoxicity](https://www.researchgate.net/publication/272373900/figure/tbl1/AS:669629584269315@1536663542176/nhibitory-effect-of-methotrexate-on-NADPH-dependent-oxidoreductases-6.png)
methotrexate glutathione Inhibitory effect of on NADPH-dependent oxidoreductases [6] the principle source of cellular energy Attenuation of methotrexate induced hepatotoxicity
Description
The results of Suofu et al
![methotrexate glutathione Inhibitory effect of on NADPH-dependent oxidoreductases [6] the principle source of cellular energy Attenuation of methotrexate induced hepatotoxicity](https://www.tandfonline.com/cms/asset/777662f4-30fc-4cc2-a0f9-e5bfbc544fd1/idct_a_2085738_uf0001_c.jpg)
Among the polyphenol class are flavonoids, which include quercetin and luteolin, both showing antioxidant and anti-inflammatory properties [91,92]
![methotrexate glutathione Inhibitory effect of on NADPH-dependent oxidoreductases [6] the principle source of cellular energy Attenuation of methotrexate induced hepatotoxicity](https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41584-022-00883-4/MediaObjects/41584_2022_883_Fig1_HTML.png)
Levels drop with stress, illness, and age
![methotrexate glutathione Inhibitory effect of on NADPH-dependent oxidoreductases [6] the principle source of cellular energy Attenuation of methotrexate induced hepatotoxicity](https://www.researchgate.net/publication/365942360/figure/fig1/AS:11431281632695832@1757653972482/MTX-driven-metabolic-perturbations-in-ALL-A-Metabolic-disturbance-caused-by-MTX_Q320.jpg)
[DOI] [PubMed] [Google Scholar] 20.Wong T., Hsu L., Liao W
