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In assumption 3, IVs can only affect the outcome through exposure, meaning no gene pleiotropy (64)
Fumarate is an oncometabolite and a potent inhibitor of prolyl 4-hydroxylase (P4H), which is a negative regulator of HIF-1
Fe3+ also induces hyperphosphorylated aggregation by binding to the histidine residues of (4446)
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