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However, comparison of caffeine or saline pretreatment under alcohol treatment, pairwise PLS-DA model saline-alcohol vs caffeine-alcohol (CER = 0.36) revealed that caffeine had a completely opposite effect on carnitines under alcohol treatment

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Diagnosis To diagnose CHE, the patient must have 1) a disease that can lead to CHE, such as liver cirrhosis or a portosystemic shunt, 2) no other neurological disease, 3) no neurological manifestation such as disorientation or asterixis, and 4) abnormal cognitive or neurophysiologic functioning

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