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doi: 10.1056/NEJM199401133300208
It should be noted, however, that these observations were made using animal microsomes and thus their relevance to acetaminophen metabolism in humans still needs to be investigated
Experimental evidence from knockout models suggests that reduced NNMT activity is associated with resistance to tumor formation, leading to speculation about a possible role for this enzyme in cancer biology
doi: 10.1186/s12967-022-03523-3 61 Rotovnik KozjekNKompanLagarTMrevlje
